Candida glabrata is an opportunistic pathogen that contributes to mucosal and systemic yeast infections. Here we use Tn-seq technology to investigate how this yeast defends against one of our best classes of antifungals. Surprisingly, we find Pdr1 promotes resistance to micafungin in addition to its well-known effect on fluconazole resistance. Drugging of Pdr1 could improve antifungal therapies.
Transposon-sequencing (Tn-seq) of the Candida glabrata reference strain CBS138 reveals epigenetic plasticity, structural variation, and intrinsic mechanisms of resistance to micafungin
Kyle Cunningham
and Timothy J. Nickels, Andrew N. Gale, Abigail A. Harrington, Winston Timp |
G3 (Bethesda), 2024