Piwi-interacting RNAs (piRNAs) are essential for animal fertility, playing crucial roles in silencing repetitive elements and endogenous genes within the germline. Their expression is regulated in a sex-specific manner. Here, we identify the first sex-specific transcription factor responsible for driving male piRNA expression.
SNPC-1.3 is a sex-specific transcription factor that drives male piRNA expression in C. elegans
John Kim
and Charlotte P Choi, Rebecca J Tay, Margaret R Starostik, Suhua Feng, James J Moresco, Brooke E Montgomery, Emily Xu, Maya A Hammonds, Michael C Schatz, Taiowa A Montgomery, John R Yates III, Steven E Jacobsen |
eLife, 2021