By combining biochemistry, super-resolution microscopy, and genetics, this study identifies Skp1 proteins as the final missing component of the synaptonemal complex (SC) in C. elegans. This breakthrough has allowed us to reconstitute a complete soluble SC building block for the first time in any organism.
Skp1 proteins are structural components of the synaptonemal complex in C. elegans
Yumi Kim
and Joshua M. Blundon, Brenda I. Cesar, Jung Woo Bae, Ivana Cavka, Joceyn Haversat, Jonas Ries, Simone Kohler |
Science Advances, 2024