Quantitative microscopy has revealed that germ granule formation in Drosophila is primarily driven by proteins rather than mRNAs. This distinguishes germ granules from other RNA granules, such as stress granules and P-bodies, which rely on RNA-dependent condensation. Additionally, germ granules are associated with the endoplasmic reticulum (ER) and nuclear pores, suggesting that these structures may work together to regulate the establishment of the germline.
Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila
Tatjana Trcek
and Harrison A. Curnutte, Xinyue Lan, Manuel Sargen, Si Man Ao leong, Dylan Campbell, Hyosik Kim, Yijun Liao, Sarah Bailah Lazar |
Cell Reports, 2023