Steven A. Farber and James H. Thierer, Ombretta Foresti, Pradeep Kumar Yadav, Meredith H. Wilson, Tabea O. C. Moll, Meng-Chieh Shen, Elisabeth M Busch-Nentwich, Margaret Morash, Karen L. Mohlke, John F. Rawls, Vivek Malhotra, M. Mahmood Hussain | Nature Communications, 2024 

Vertebrates needed to expand the size of lipoprotein cargos and in the absence of Pla2g12b produce invertebrate like small lipoproteins that are incapable of producing atherogenic plaques. Pla2g12b primarily acts in the ER by binding both lipids, lipid transfer protein and lipoprotein to facilitate ER lipid transfer and lipoprotein particle expansion.