Parasitic nematodes infect billions of people yet we have limited drugs to treat these infections. Here, we discovered the first novel mechanism of benzimidazole resistance in over forty years.
Naturally occurring variation in a cytochrome P450 modifies thiabendazole responses independently of beta-tubulin
Erik Andersen
and J. B. Collins, Clayton M. Dilks, Steffen R. Hahnel, Briana Rodriguez, Bennett W. Fox, Elizabeth Redman, Jingfang Yu, Brittany Cooke, Kateryna Sihuta, Mostafa Zamanian, Peter J. Roy, Frank C. Schroeder, John S. Gilleard |
PLOS Pathogens, 2025