DNA replication is the most fundamental biological process and is indispensable for cell function. Recently, my lab has made a novel discovery: Reducing the activity of a single DNA replication component, DNA polymerase a, could enhance cellular plasticity and improve tissue function across diverse systems and species.
Increased levels of lagging strand polymerase α in an adult stem cell lineage affect replication-coupled histone incorporation
Xin Chen
and Brendon E. M. Davis, Jonathan Snedeker, Rajesh Ranjan, Matthew Wooten, Savannah Sade Barton, Joshua Blundon |
Science Advances, 2025