Macromolecular complexes are often composed of diverse subunits. Assembling these monomeric subunits into complexes over time faces fundamental obstacles that can be robustly overcome by exploiting a large design space of kinetic protocols.
Discovering optimal kinetic pathways for self-assembly using automatic differentiation
Margaret Johnson
and Adip Jhaveri, Spencer Loggia, Yian Qian |
Proceedings of the National Academy of Sciences of the United States of America, 2024