Quantitative microscopy has revealed that germ granule formation in Drosophila is primarily driven by proteins rather than mRNAs. This distinguishes germ granules from other RNA granules, such as stress granules and P-bodies, which rely on RNA-dependent condensation. Additionally, germ granules are associated with the endoplasmic reticulum (ER) and nuclear pores, suggesting that these structures may […]

Trichromacy is unique to primates among placental mammals, enabled by blue, green, and red cones. Our study of human retinas and organoids revealed that timing of retinoic acid signaling regulates the decision between green and red cone fates. 

DNA replication is the most fundamental biological process and is indispensable for cell function. Recently, my lab has made a novel discovery: Reducing the activity of a single DNA replication component, DNA polymerase a, could enhance cellular plasticity and improve tissue function across diverse systems and species.

This paper demonstrates that the sex of germline stem cells (male or female) influence how they respond to signals in their surrounding niche environment.