Vertebrates needed to expand the size of lipoprotein cargos and in the absence of Pla2g12b produce invertebrate like small lipoproteins that are incapable of producing atherogenic plaques. Pla2g12b primarily acts in the ER by binding both lipids, lipid transfer protein and lipoprotein to facilitate ER lipid transfer and lipoprotein particle expansion.

This study reveals that the lack of regular environmental light negatively influences glucose and lipid metabolism and that the sympathetic nervous system mediates such an effect.

By combining biochemistry, super-resolution microscopy, and genetics, this study identifies Skp1 proteins as the final missing component of the synaptonemal complex (SC) in C. elegans. This breakthrough has allowed us to reconstitute a complete soluble SC building block for the first time in any organism.