The SWR1 chromatin remodeling complex is recruited to +1 nucleosomes downstream of transcription start sites of eukaryotic promoters, where it exchanges histone H2A for the specialized variant H2A.Z. Here, we use cryoelectron microscopy (cryo-EM) to resolve the structural basis of the SWR1 interaction with free DNA, revealing a distinct open conformation of the Swr1 ATPase that […]
Research Highlight Category: Biochemistry and Biophysics
Structure of an endogenous mycobacterial MCE lipid transporter
Our data lead to a structural model for Mce1-mediated lipid import across the mycobacterial cell envelope.