Siran Tian

Siran Tian

Research Lab: Trcek

Trained to be a researcher

Before joining the Hopkins CMDB program, I completed my undergraduate studies at Emory University in Georgia, where I majored in behavioral biology. My research experience was highly translational, involving work with patient-derived samples and human responses to environmental hazards. Although this experience laid the foundation for my passion for research, I soon realized that I needed more systematic training. Without such guidance, I would remain merely a pair of hands in the lab rather than leading my own projects independently in the future.

When applying to graduate programs, I sought an environment that would transform me into a well-rounded researcher, not just an experienced technician with a PhD. I wanted to master not only experimental techniques but also effective writing, public speaking, mentorship, and collaboration. That is why I chose to join the CMDB program in 2019. I truly believed it was the right place for me to grow as a scientist.

Embracing the unknown

I joined Dr. Tatjana Trcek’s lab, where I use Drosophila (fruit flies) as a model system to study RNA:RNA interactions within a type of membraneless biomolecular condensates called “germ granules.” Before starting my PhD journey, I never imagined that I would be working with fruit flies or their eggs would become the focus of my PhD thesis. These tiny bugs that once buzzed around my food have now become critical experimental subjects, and the possibility that my findings from them could be relevant to other organisms continues to amaze me.

One of the most exciting aspects of my project is that the field of biomolecular condensates remains relatively underexplored. Although many people compare the formation of these granules to the way oil and water separate, the fundamental principles governing their formation and their roles in cellular functions and human diseases are still largely unknown. Each breakthrough, whether from our lab or others, represents a significant step toward a deeper understanding of this intriguing area. That’s what excites me every day in the lab. 

A supportive scientific family

Working in Dr. Trcek’s lab feels like being part of a family. Every member is incredibly supportive. We regularly exchange ideas and are willing to help each other succeed and thrive. Research is inherently challenging. The majority of our time in the lab is troubleshooting or experiencing setbacks. However, being with my lab members helps me remain motivated even when my progress is slow. And when successes do occur, we celebrate them together.

Additionally, Dr. Trcek is an inspiring mentor. She trains us to critically evaluate our results and the work of others, emphasizing the importance of clear and persuasive scientific communication. Because English is not my native language, I initially struggled with writing. However, Dr. Trcek patiently revises my work and teaches me to write effectively, which has transformed my approach to scientific writing. I now appreciate the power of language in conveying complex ideas. Moreover, she teaches us that there are no “bad” data. When I present negative results to her, she encourages me to view them positively, always reminding me that “it is what it is. You can’t twist the data, and we are not married to any particular model.”

Life outside the lab

Baltimore offers an affordable cost of living for graduate students who rely heavily on stipends. Living here, I can focus on my research without unnecessary financial pressure. In addition, the city is far from an isolated “research island”, it is a vibrant urban center with easy access to other major cities like D.C., Rockville, and Tyson, all within a short drive or train ride. Whenever I need a break for a day of food, shopping, or cultural events, I can easily go to these places and recharge myself.